The plant Sida cordifolia belongs to family Malvaceae is used in treatment of cancer. On cytotoxic studies of methanolic extract of the native plant possess cytotoxic activity. The in vitro produced callus in MS media with 2,4-D and BA were subcultured into MS medium with different plant growth regulators. The methanolic extracts of these calli were subjected to antibacterial screening. Methanol extract of callus produced from the combination of NAA (1.00 mg/l) + Kinetin (1.00 mg/l) was found to more active than the native plant extract. On GCMS analysis the bioactive compounds vasicine and ephedrine were identified and they are more in vitro produced callus compared to native plant. The natural extract possesses antitumour activity on cytotoxicity assay.
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